Hi Vetrivel,
Please check in RZ10 whether these two parameters are there or not. If not , add it.
icm/server_port_2 = PROT=SMTP, PORT =25000, TIMEOUT = 180
is/SMTP/virt_host_0 = *:25000;
Please note that first apply on DEVELOPMENT server , the only in any other system.
I have given the above two parameters, and it started working for me .
Regards
Praveen